Dietary intake is associated with respiratory health outcomes and DNA methylation in children with asthma.

ABSTRACT:

Background

Asthma is an increasingly common chronic disease among children, and data point toward a complex mechanism involving genetic, environmental and epigenetic factors. Epigenetic modifications such as DNA hypo- or hyper-methylation have been shown to occur in response to environmental exposures including dietary nutrients.

Methods

Within the context of the asthma randomized trial of indoor wood smoke (ARTIS) study, we investigated relationships between diet, asthma health measures, and DNA methylation. Asthma health measures included a quality of life instrument, diurnal peak flow variability (dPFV) and forced expiratory volume in the first second (FEV₁). Dietary intake was assessed with a food frequency questionnaire. Methylation levels of LINE-1 repetitiv

SUBMITTER: Montrose L 

PROVIDER: S-EPMC5327515 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature