Nanoparticles Formed by Acoustic Destruction of Microbubbles and Their Utilization for Imaging and Effects on Therapy by High Intensity Focused Ultrasound.

ABSTRACT: This work reports that when PEG-lipid-shelled microbubbles with fluorocarbon interior (C₄F₁₀, C₅F₁₂, or C₆F₁₄) are subjected to ultrasound pulses, they produce metastable, fluid-filled nanoparticles that can be re-imaged upon administration of HIFU. The nanoparticles produced by destruction of the microbubbles (MBNPs) are of 150 nm average diameter and can be re-imaged for up to an hour after creation for C ₄F₁₀, and for at least one day for C₅F₁₂. The active species were found to be fluid (gas or liquid) filled nanoparticles rather than lipid debris. The acoustic droplet vaporization threshold of the nanoparticles was found to vary with the vapor pressure of the encapsulated fluor

SUBMITTER: Blum NT 

PROVIDER: S-EPMC5327643 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature