Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.

ABSTRACT: Copy number alteration (CNA) profiling of human tumors has revealed recurrent patterns of DNA amplifications and deletions across diverse cancer types. These patterns are suggestive of conserved selection pressures during tumor evolution but cannot be fully explained by known oncogenes and tumor suppressor genes. Using a pan-cancer analysis of CNA data from patient tumors and experimental systems, here we show that principal component analysis-defined CNA signatures are predictive of glycolytic phenotypes, including ¹⁸F-fluorodeoxy-glucose (FDG) avidity of patient tumors, and increased proliferation. The primary CNA signature is enriched for p53 mutations and is associated with glycolysis through coordinate amplification of glycolytic genes and other cancer-linked metabolic enzy

SUBMITTER: Graham NA 

PROVIDER: S-EPMC5327725 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature