Delivery of nicotine aerosol to mice via a modified electronic cigarette device.

ABSTRACT:

Background

Although both men and women use e-cigarettes, most preclinical nicotine research has focused on its effects in male rodents following injection. The goals of the present study were to develop an effective e-cigarette nicotine delivery system, to compare results to those obtained after subcutaneous (s.c.) injection, and to examine sex differences in the model.

Methods

Hypothermia and locomotor suppression were assessed following aerosol exposure or s.c. injection with nicotine in female and male mice. Subsequently, plasma and brain concentrations of nicotine and cotinine were measured.

Results

Passive exposure to nicotine aerosol produced concentration-dependent and mecamylamine reversible hypothermic and locomotor suppressant effects in female and male mice

SUBMITTER: Lefever TW 

PROVIDER: S-EPMC5327853 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature