Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection.

ABSTRACT: CD73-derived adenosine plays an anti-inflammatory role in various organs. However, its role in renal ischemia-reperfusion injury (IRI) is controversial. We targeted CD73 mutant mice to determine the function of CD73 expressed by various renal cell types under mild IRI conditions. Mice with CD73 deletion in proximal tubules exhibited exacerbated IRI, comparable with that of CD73^-/- mice compared with WT mice. Mice with CD73 deletions in other cell types, including cortical type 1 fibroblast-like cells, mesangial cells, macrophages, and dendritic cells, showed small or no increases in injury above control mice when subjected to threshold levels of ischemia. Results from adoptive transfer experiments between WT and CD73^-/- mice and pharmacologic studies mod

SUBMITTER: Sung SJ 

PROVIDER: S-EPMC5328157 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature