African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.

ABSTRACT: African ancestry alleles may contribute to CKD among Hispanics/Latinos, but whether associations differ by Hispanic/Latino background remains unknown. We examined the association of CKD measures with African ancestry-specific APOL1 alleles that were directly genotyped and sickle cell trait (hemoglobin subunit β gene [HBB] variant) on the basis of imputation in 12,226 adult Hispanics/Latinos grouped according to Caribbean or Mainland background. We also performed an unbiased genome-wide association scan of urine albumin-to-creatinine ratios. Overall, 41.4% of participants were male, 44.6% of participants had a Caribbean background, and the mean age of all participants was 46.1 years. The Caribbean background group, compared with the Mainland background group, had a high

SUBMITTER: Kramer HJ 

PROVIDER: S-EPMC5328161 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature