SP110b Controls Host Immunity and Susceptibility to Tuberculosis.

ABSTRACT:

Rationale

How host genetic factors affect Mycobacterium tuberculosis (Mtb) infection outcomes remains largely unknown. SP110b, an IFN-induced nuclear protein, is the nearest human homologue to the mouse Ipr1 protein that has been shown to control host innate immunity to Mtb infection. However, the function(s) of SP110b remains unclear.

Objectives

To elucidate the role of SP110b in controlling host immunity and susceptibility to tuberculosis (TB), as well as to identify the fundamental immunological and molecular mechanisms affected by SP110b.

Methods

Using cell-based approaches and mouse models of Mtb infection, we characterized the function(s) of SP110b/Ipr1. We also performed genetic characterization of patients with TB to investigate the role of SP110 in controllin

SUBMITTER: Leu JS 

PROVIDER: S-EPMC5328177 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature