Benefit of adjuvant immunotherapy in renal cell carcinoma: A myth or a reality?

ABSTRACT:

Background

The benefit of adjuvant immunotherapy after nephrectomy in renal cell carcinoma (RCC) is controversial. The present study aimed to examine the possible benefit of adjuvant immunotherapy in various clinical settings.

Methods

We retrospectively reviewed 436 patients with pT1-3N0-2M0 RCC who underwent radical or partial nephrectomy with curative intent at our institution between 1981 and 2009. Of them, 98 (22.5%) patients received adjuvant interferon-α (IFN-α) after surgery (adjuvant IFN-α group), while 338 (77.5%) did not (control group). The primary endpoint was cancer-specific survival (CSS). Univariate and multivariate analyses were conducted using log-rank tests and Cox proportional hazards models, respectively.

Results

Fifty-two (11.9%) patients died fro

SUBMITTER: Taguchi S 

PROVIDER: S-EPMC5328261 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature