Applicability of Clinical Trials in an Unselected Cohort of Patients With Intracerebral Hemorrhage.

ABSTRACT:

Background and purpose

Patient selection in clinical trials on intracerebral hemorrhage (ICH) affects overall applicability of results. We estimated eligibility for completed, ongoing, and planned clinical trials in an unselected cohort of patients with ICH.

Methods

Large clinical ICH trials were identified using trial registration databases. Each trial's inclusion criteria were applied to a consecutive group of patients with ICH from the prospective hospital-based Lund Stroke Register. Survival status was obtained from the National Census Office and 90-day poor functional outcome (modified Rankin Scale ≥4) from the Swedish Stroke Register or medical files.

Results

Among 253 patients with ICH, estimated eligibility proportions ranged between 2% and 36% for the 11 iden

SUBMITTER: Hansen BM 

PROVIDER: S-EPMC5328273 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature