Metronomic treatment of advanced non-small-cell lung cancer with daily oral vinorelbine - a Phase I trial.

ABSTRACT:

Micro-abstract

In a Phase I dose-finding study of metronomic daily oral vinorelbine in advanced non-small-cell lung cancer, a recommended dose was established for this therapeutic approach. In addition, this trial revealed promising efficacy data and an acceptable tolerability profile. The observed vinorelbine blood concentrations suggest continuous anti-angiogenic coverage.

Introduction

We present a Phase I dose-finding study investigating metronomic daily oral vinorelbine (Navelbine^® Oral, NVBo) in advanced non-small-cell lung cancer (NSCLC).

Patients and methods

Patients with stage III/IV NSCLC received daily NVBo at fixed dose levels of 20-50 mg/d for 21 days of each 4-week cycle. Primary end point was the maximum tolerated dose. Secondary end points in

SUBMITTER: Guetz S 

PROVIDER: S-EPMC5328303 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature