Tau or neurofilament light-Which is the more suitable biomarker for Huntington's disease?

ABSTRACT:

Introduction

Previous studies have suggested cerebrospinal fluid (CSF) levels of neurofilament light (NFL) and total tau are elevated in Huntington's disease (HD) and may be used as markers of disease stage. Biomarkers are needed due to the slow disease progression and the limitations of clinical assessment. This study aims to validate the role of NFL and tau as biomarkers in HD.

Methods

CSF was obtained from a cohort of HD patients and premanifest HD-mutation carriers. Unified Huntington's Disease Rating Scale (UHDRS) testing was performed on all subjects at the time of sampling. NFL and tau concentrations were determined by ELISA. Spearman correlations were calculated with R version 3.2.3.

Results

11 premanifest HD and 12 manifest HD subjects were enrolled. NFL and

SUBMITTER: Niemela V 

PROVIDER: S-EPMC5328385 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature