The Transcriptional Regulator CpsY Is Important for Innate Immune Evasion in Streptococcus pyogenes.

ABSTRACT: As an exclusively human pathogen, Streptococcus pyogenes (the group A streptococcus [GAS]) has specifically adapted to evade host innate immunity and survive in multiple tissue niches, including blood. GAS can overcome the metabolic constraints of the blood environment and expresses various immunomodulatory factors necessary for survival and immune cell resistance. Here we present our investigation of one such factor, the predicted LysR family transcriptional regulator CpsY. The encoding gene, cpsY, was initially identified as being required for GAS survival in a transposon-site hybridization (TraSH) screen in whole human blood. CpsY is homologous with transcriptional regulators of Streptococcus mutans (MetR), Streptococcus iniae (CpsY), and Streptococcus aga

SUBMITTER: Vega LA 

PROVIDER: S-EPMC5328483 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature