Streptococcus oralis Neuraminidase Modulates Adherence to Multiple Carbohydrates on Platelets.

ABSTRACT: Adherence to host surfaces is often mediated by bacterial binding to surface carbohydrates. Although it is widely appreciated that some bacterial species express glycosidases, previous studies have not considered whether bacteria bind to multiple carbohydrates within host glycans as they are modified by bacterial glycosidases. Streptococcus oralis is a leading cause of subacute infective endocarditis. Binding to platelets is a critical step in disease; however, the mechanisms utilized by S. oralis remain largely undefined. Studies revealed that S. oralis, like Streptococcus gordonii and Streptococcus sanguinis, binds platelets via terminal sialic acid. However, unlike those organisms, S. oralis produces a neuraminidase, NanA, which cleaves terminal sialic acid. Further studies revealed tha

SUBMITTER: Singh AK 

PROVIDER: S-EPMC5328485 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature