Immunomodulatory effects of coated gold nanoparticles in LPS-stimulated in vitro and in vivo murine model systems.

ABSTRACT: The ability of nanoparticle surface functionalities to regulate immune responses during an immunological challenge (i. e. inflammation) would open new doors for their use in non-prophylactic therapeutics. We report here the use of functionalized 2 nm core gold nanoparticles to control the immunological responses of in vitro and in vivo systems presented with an inflammatory challenge. The results showed that NPs bearing a hydrophobic zwitterionic functionality boost inflammatory outcomes while hydrophilic zwitterionic NPs generate minimal immunological responses. Surprisingly, tetra(ethylene glycol) headgroups generate a significant anti-inflammatory response both in vitro and in vivo. These results demonstrate the ability of simple surface ligands to provide im

SUBMITTER: Moyano DF 

PROVIDER: S-EPMC5328597 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature