Gender differences in the association between HTR2C gene variants and suicidal behavior in a Mexican population: a case-control study.

ABSTRACT:

Background

The aim of this case-control study was to explore the association by gender between the HTR2C gene variants and suicidal behavior in a Mexican population.

Subjects and methods

A total of 183 suicide attempters and 208 healthy volunteers were included in this study. We genotyped five polymorphisms of HTR2C (rs547536, rs2192372, rs4272555, rs6318, and rs2428707), then measured the association by genotype, allele, and haplotype.

Results

In the female group, we found an association between two polymorphisms of the HTR2C (rs4272555 and rs2428707) and suicide attempts. The C allele of the single-nucleotide polymorphism (SNP) rs4272555 was associated with a decreased risk of suicide attempt (P=0.01, odds ratio =0.26, 95% confidence interval: 0.09-0.7

SUBMITTER: Molina-Guzman G 

PROVIDER: S-EPMC5328611 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature