Body mass index and risk of colorectal cancer according to tumor lymphocytic infiltrate.

ABSTRACT: Higher body mass index (BMI), higher body adiposity and obesity have been associated with increased risk of colorectal cancer. Evidence suggests that excess energy balance may influence systemic immune and inflammatory status. Thus, we hypothesized that the positive association between BMI and colorectal cancer risk might differ according to colorectal carcinoma subtypes according to levels of histopathological lymphocytic reaction to tumor. We collected biennial questionnaire data on weight and baseline height information in two prospective cohort studies, the Nurses' Health Study (1980-2010) and the Health Professionals Follow-up Study (1986-2010). Utilizing duplication-method Cox proportional hazards regression models, we prospectively assessed the association between BMI and risk of co

SUBMITTER: Hanyuda A 

PROVIDER: S-EPMC5328655 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature