In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis.

ABSTRACT:

Objective

Antiphospholipid syndrome (APS) is a leading acquired cause of thrombotic events. Although antiphospholipid antibodies have been shown to promote thrombosis in mice, the role of neutrophils has not been explicitly studied. The aim of this study was to characterize neutrophils in the context of a new model of antiphospholipid antibody-mediated venous thrombosis.

Methods

Mice were administered fractions of IgG obtained from patients with APS. At the same time, blood flow through the inferior vena cava was reduced by induction of stenosis. Resulting thrombi were characterized for size and neutrophil content. Circulating factors and the vessel wall were also assessed.

Results

As measured by both thrombus weight and thrombosis frequency, mice treated with IgG fro

SUBMITTER: Meng H 

PROVIDER: S-EPMC5329054 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature