Genetic variants at 9p21.3 are associated with risk of esophageal squamous cell carcinoma in a Chinese population.

ABSTRACT: Genome-wide association studies have linked genetic variants at 9p21.3 to the risk of multiple cancers. However, the roles of genetic variants at 9p21.3 in esophageal squamous cell carcinoma (ESCC) development are largely unknown. We evaluated the genetic variants at 9p21.3 reported in cancer genome-wide association studies with a case-control study including 2139 ESCC cases and 2273 controls in a Chinese population, and measured the mRNA expression levels of MTAP, CDKN2A, CDKN2B, and CDKN2B-AS1 in paired ESCC tumor and adjacent normal tissues. We found that the G allele of rs7023329 was significantly associated with a decreased risk of ESCC with a per-allele odds ratio of 0.84 (95% confidence interval, 0.77-0.91; P = 2.95 × 10^-5 ). The rs7023329-G allele was related to a high e

SUBMITTER: Lin X 

PROVIDER: S-EPMC5329157 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature