Systemic Therapy for Early-Stage Breast Cancer: What the Plastic Surgeon Should Know.

ABSTRACT: Objective: We review the types, indications, and common regimens of systemic forms of therapy offered in early-stage breast cancer. We further detail the mechanism of action, approved uses, major toxicities, and relevance to breast reconstruction of specific agents. Methods: A review of the literature on PubMed and Cochrane databases was undertaken to define the indications and common regimens of systemic therapy in early-stage breast cancer. In addition, literature describing relevant information regarding specific systemic agents was reviewed. Results: The main objectives of systemic therapy, when provided in the perioperative setting, are to reduce the risk for future recurrence and prolong overall survival. Systemic forms of therapy consist of chemotherapy, hormona

SUBMITTER: Teven CM 

PROVIDER: S-EPMC5329939 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature