Differential correlation analysis of glioblastoma reveals immune ceRNA interactions predictive of patient survival.

ABSTRACT:

Background

Recent studies illuminated a novel role of microRNA (miRNA) in the competing endogenous RNA (ceRNA) interaction: two genes (ceRNAs) can achieve coexpression by competing for a pool of common targeting miRNAs. Individual biological investigations implied ceRNA interaction performs crucial oncogenic/tumor suppressive functions in glioblastoma multiforme (GBM). Yet, a systematic analysis has not been conducted to explore the functional landscape and prognostic significance of ceRNA interaction.

Results

Incorporating the knowledge that ceRNA interaction is highly condition-specific and modulated by the expressional abundance of miRNAs, we devised a ceRNA inference by differential correlation analysis to identify the miRNA-modulated ceRNA pairs. Analyzing sample-paired

SUBMITTER: Chiu YC 

PROVIDER: S-EPMC5330036 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature