The effect of size-segregated ambient particulate matter on Th1/Th2-like immune responses in mice.

ABSTRACT:

Background

Particulate matter (PM) has been associated with increased pulmonary and cardiovascular mortality and morbidity. Additionally, PM is known to exacerbate asthma. However, whether ambient PM exposure contributes to the onset of asthma, especially in non-atopic children and adults, is less conclusive. The current study aimed to evaluate the effects of size-fractioned PM on lung immune responses in healthy BALB/c mice.

Methods and principal findings

We collected PM10, PM2.5, PM1 and PM0.1 samples from October 2012 to August 2013 in the Taipei Basin. These PM samples were representative of urban traffic pollution. The samples were extracted and sonicated in phosphate-buffered saline (PBS). Female BALB/c mice were exposed to the samples via intratracheal instillation at

SUBMITTER: Huang KL 

PROVIDER: S-EPMC5330505 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature