A Canadian perspective on the subcutaneous administration of rituximab in non-Hodgkin lymphoma.

ABSTRACT: Rituximab is widely used for the treatment of non-Hodgkin lymphoma, being a key component in most therapeutic regimens. Administration of the intravenous (IV) formulation is lengthy and places a significant burden on health care resources and patient quality of life. A subcutaneous (sc) formulation that provides a fixed dose of rituximab is being examined in a number of studies. Results indicate that the pharmacokinetics are noninferior and response rates are comparable to those obtained with the IV formulation. Moreover, the sc formulation is preferred by patients and health care providers and reduces administration and chair time. Additional advantages include a lesser potential for dosing errors, shorter preparation time, reduced drug wastage, and fewer infusion-related reactions. Despi

SUBMITTER: MacDonald D 

PROVIDER: S-EPMC5330627 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature