Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation.

ABSTRACT: Gene-expression profiling has become a mainstay in immunology, but subtle changes in gene networks related to biological processes are hard to discern when comparing various datasets. For instance, conservation of the transcriptional response to sepsis in mouse models and human disease remains controversial. To improve transcriptional analysis in immunology, we created ImmuneSigDB: a manually annotated compendium of ∼5,000 gene-sets from diverse cell states, experimental manipulations, and genetic perturbations in immunology. Analysis using ImmuneSigDB identified signatures induced in activated myeloid cells and differentiating lymphocytes that were highly conserved between humans and mice. Sepsis triggered conserved patterns of gene expression in humans and mouse models. However, we also

SUBMITTER: Godec J 

PROVIDER: S-EPMC5330663 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature