Ontology highlight
ABSTRACT:
SUBMITTER: Kent LN
PROVIDER: S-EPMC5330731 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20170130 3
Disruption of the retinoblastoma (RB) tumor suppressor pathway, either through genetic mutation of upstream regulatory components or mutation of RB1 itself, is believed to be a required event in cancer. However, genetic alterations in the RB-regulated E2F family of transcription factors are infrequent, casting doubt on a direct role for E2Fs in driving cancer. In this work, a mutation analysis of human cancer revealed subtle but impactful copy number gains in E2F1 and E2F3 in hepatocellular carc ...[more]