Histopathological Differences Between the Anterior and Posterior Brain Arteries as a Function of Aging.

ABSTRACT:

Background and purpose

We tested the hypothesis that posterior brain arteries differ pathologically from anterior brain arteries and that this difference varies with age.

Methods

Brain large arteries from 194 autopsied individuals (mean age 56±17 years, 63% men, 25% nonwhite, 17% with brain infarcts) were analyzed to obtain the areas of arterial layers and lumen as well as the relative content of elastin, collagen, and amyloid. Visual rating was used to determine the prevalence of atheroma, calcification, vasa vasorum, pattern of intima thickening, and internal elastic lamina gaps. We used multilevel models adjusting for age, sex, ethnicity, vascular risk factors, artery type and location, and multiple comparisons.

Results

Of 1362 large artery segments, 5% had

SUBMITTER: Roth W 

PROVIDER: S-EPMC5330785 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature