Rapid Integration of Artificial Sensory Feedback during Operant Conditioning of Motor Cortex Neurons.

ABSTRACT: Neuronal motor commands, whether generating real or neuroprosthetic movements, are shaped by ongoing sensory feedback from the displacement being produced. Here we asked if cortical stimulation could provide artificial feedback during operant conditioning of cortical neurons. Simultaneous two-photon imaging and real-time optogenetic stimulation were used to train mice to activate a single neuron in motor cortex (M1), while continuous feedback of its activity level was provided by proportionally stimulating somatosensory cortex. This artificial signal was necessary to rapidly learn to increase the conditioned activity, detect correct performance, and maintain the learned behavior. Population imaging in M1 revealed that learning-related activity changes are observed in the conditioned cell o

SUBMITTER: Prsa M 

PROVIDER: S-EPMC5330804 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature