Cerebral Microbleeds as Predictors of Mortality: The Framingham Heart Study.

ABSTRACT:

Background and purpose

Cerebral microbleeds (CMB) represent a common magnetic resonance imaging marker of cerebral small vessel disease, increasingly recognized as a subclinical marker of stroke and dementia risk. CMB detection may reflect the cumulative effect of vascular risk burden and be a marker of higher mortality. We investigated the relation of CMB to risk of death in community dwelling participants free of stroke and dementia.

Methods

We evaluated 1963 Framingham Original and Offspring Cohort participants (mean age 67 years; 54% women) with available brain magnetic resonance imaging and mortality data. Using Cox proportional hazards models, we related CMB to all-cause, cardiovascular, and stroke-related mortality.

Results

Participants with CMB (8.9%) had high

SUBMITTER: Romero JR 

PROVIDER: S-EPMC5330856 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature