Fc microparticles can modulate the physical extent and magnitude of complement activity.

ABSTRACT: The complement system is an integral component of the humoral immune system, and describes a cascade of interacting proteins responsible for the opsonization and lysis of foreign pathogens, in addition to the recruitment of immune cells. However, complement activation is also implicated in the progression and complication of immune dysfunctions such as sepsis. Microparticle (MP) biomaterials capable of tuning the local magnitude of serum complement activation could improve complement-mediated cytotoxicity to serum-resistant bacteria or calm an overactive immune response during sepsis. We demonstrate that model Fc-functionalized microparticles can be designed to either enhance or diminish the local cytotoxic effect of complement activation in human serum. The particles were formed with eith

SUBMITTER: Holt BA 

PROVIDER: S-EPMC5330945 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature