Cognitive behavioral therapy increases amygdala connectivity with the cognitive control network in both MDD and PTSD.

ABSTRACT:

Background

Both major depressive disorder (MDD) and post-traumatic stress disorder (PTSD) are characterized by alterations in intrinsic functional connectivity. Here we investigated changes in intrinsic functional connectivity across these disorders as a function of cognitive behavioral therapy (CBT), an effective treatment in both disorders.

Methods

53 unmedicated right-handed participants were included in a longitudinal study. Patients were diagnosed with PTSD (n = 18) and MDD (n = 17) with a structured diagnostic interview and treated with 12 sessions of manualized CBT over a 12-week period. Patients received an MRI scan (Siemens 3 T Trio) before and after treatment. Longitudinal functional principal components analysis (LFPCA) was performed on functional co

SUBMITTER: Shou H 

PROVIDER: S-EPMC5331144 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature