Insulin secretagogue use and circulating inflammatory C-C chemokine levels in breast cancer patients.

ABSTRACT: Monocytes' infiltration into the tumor tissue and their activation to tumor-associated macrophages is an essential step in tumor development, also playing a critical role in an eventual metastasis. Stimulation of endogenous insulin production by oral insulin secretagogue treatment has the potential to interfere with the production and release of C-C chemokines, a group of potent inflammatory cytokines acting as monocyte chemo-attractants and influencing their behavior in the tumor microenvironment. Studied plasma samples were collected under a previously reported study design involving a population of women diagnosed with breast cancer presenting with or without type 2 diabetes mellitus at the time of breast cancer diagnosis (Wintrob et al., 2017, 2016) [1,2]. The data presented here shows

SUBMITTER: Wintrob ZA 

PROVIDER: S-EPMC5331147 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature