Optimally Repeatable Kinetic Model Variant for Myocardial Blood Flow Measurements with ⁸²Rb PET.

ABSTRACT: Purpose. Myocardial blood flow (MBF) quantification with ⁸²Rb positron emission tomography (PET) is gaining clinical adoption, but improvements in precision are desired. This study aims to identify analysis variants producing the most repeatable MBF measures. Methods. 12 volunteers underwent same-day test-retest rest and dipyridamole stress imaging with dynamic ⁸²Rb PET, from which MBF was quantified using 1-tissue-compartment kinetic model variants: (1) blood-pool versus uptake region sampled input function (Blood/Uptake-ROI), (2) dual spillover correction (SOC-On/Off), (3) right blood correction (RBC-On/Off), (4) arterial blood transit delay (Delay-On/Off), and (5) distribution volume (DV) constraint (Global/Regional-DV). Repeatability of MBF, stress/r

SUBMITTER: Ocneanu AF 

PROVIDER: S-EPMC5331165 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature