Neuroplastic changes in patients with schizophrenia undergoing cognitive remediation: triple-blind trial.

ABSTRACT: BackgroundPatients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.AimsTo use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).MethodTwenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.ResultsWe observed a group × time interaction i

SUBMITTER: Ramsay IS 

PROVIDER: S-EPMC5331188 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature