A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues.

ABSTRACT: For the synthesis of m-sulfamoylbenzamide analogues, small molecules which are known for their bioactivity, a chemoselective procedure has been developed starting from m-(chlorosulfonyl)benzoyl chloride. Although a chemoselective process in batch was already reported, a continuous-flow process reveals an increased selectivity at higher temperatures and without catalysts. In total, 15 analogues were synthesized, using similar conditions, with yields ranging between 65 and 99%. This is the first automated and chemoselective synthesis of m-sulfamoylbenzamide analogues.

SUBMITTER: Verlee A 

PROVIDER: S-EPMC5331323 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature