The rs6817105 polymorphism on chromosome 4q25 is associated with the risk of atrial fibrillation in the Chinese Han population.

ABSTRACT:

Objective

Previous genome-wide association studies (GWASs) have identified rs6817105-a single nucleotide polymorphism (SNP) on chromosome 4q25-to be associated with the risk of atrial fibrillation (AF) in a European-descent population. We recently demonstrated this association in a large cohort of Japanese ancestry. Our present study was designed to determine this association in the Chinese Han population.

Methods

This case-control study included 597 AF cases and 996 AF-free controls, and rs6817105 SNPs were genotyped using the TaqMan allelic discrimination assay. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated in logistic regression models.

Results

The genotype distribution of rs6817105-CC was significantly more frequent in the AF patients tha

SUBMITTER: Fang Z 

PROVIDER: S-EPMC5331349 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature