In search of druggable targets for GBM amino acid metabolism.

ABSTRACT:

Background

Amino acid (AA) pathways may contain druggable targets for glioblastoma (GBM). Literature reviews and GBM database ( http://r2.amc.nl ) analyses were carried out to screen for such targets among 95 AA related enzymes.

Methods

First, we identified the genes that were differentially expressed in GBMs (3 datasets) compared to non-GBM brain tissues (5 datasets), or were associated with survival differences. Further, protein expression for these enzymes was also analyzed in high grade gliomas (HGGs) (proteinatlas.org). Finally, AA enzyme and gene expression were compared among the 4 TCGA (The Cancer Genome Atlas) subtypes of GBMs.

Results

We detected differences in enzymes involved in glutamate and urea cycle metabolism in GBM. For example, expression levels of

SUBMITTER: Panosyan EH 

PROVIDER: S-EPMC5331648 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature