Maternal nutrition modulates fetal development by inducing placental efficiency changes in gilts.

ABSTRACT:

Background

Intra-uterine growth restriction (IUGR) and fetal overgrowth increase risks to postnatal health. Maternal nutrition is the major intrauterine environmental factor that alters fetal weight. However, the mechanisms underlying the effects of maternal nutrition on fetal development are not entirely clear. We developed a pig model, and using isobaric tags for relative and absolute quantification (iTRAQ), we investigated alterations in the placental proteome of gilts on a normal-energy-intake (Con) and high-energy-intake (HE) diet.

Results

In the Con group, heavy and light fetuses were found at the tubal and cervical ends of the uterus respectively at 90 d of gestation. Moreover, the heavy fetuses had a higher glucose concentration than the light fetuses. However, a hig

SUBMITTER: Che L 

PROVIDER: S-EPMC5331709 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature