GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease.

ABSTRACT:

Background

Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unknown. We tested associations between GDF-15 and subclinical coronary atherosclerosis, assessed by coronary artery calcium (CAC) score, in COPD subjects free of clinical cardiovascular disease (CVD).

Methods

Cross-sectional analysis of COPD participants (GOLD stages 2-4) in the COPDGene cohort without CVD at enrollment, using baseline CAC (from non-EKG-gated chest computed tomography) and plasma GDF-15 (by custom ELISA). We used multinomial logistic modeling of GDF-15 associations with CAC, adjusting for demographics, baseline risk (calculated using the HEART: P

SUBMITTER: Martinez CH 

PROVIDER: S-EPMC5331711 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature