Repeatability of ¹⁸F-FLT PET in a Multicenter Study of Patients with High-Grade Glioma.

ABSTRACT: Quantitative 3'-deoxy-3'-¹⁸F-fluorothymidine (¹⁸F-FLT) PET has potential as a noninvasive tumor biomarker for the objective assessment of response to treatment. To guide interpretation of these quantitative data, we evaluated the repeatability of ¹⁸F-FLT PET as part of a multicenter trial involving patients with high-grade glioma. Methods:¹⁸F-FLT PET was performed on 10 patients with recurrent high-grade glioma at 5 different institutions within the Adult Brain Tumor Consortium trial ABTC1101. Data were acquired according to a double baseline protocol in which PET examinations were repeated within 2 d of each other with no intervening treatment. On each of the 2 imaging days, dedicated brain PET was performed at 2 time points, 1 and 3 h af

SUBMITTER: Lodge MA 

PROVIDER: S-EPMC5331936 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature