Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling.

ABSTRACT: During development, progenitor expansion, lineage allocation, and implementation of differentiation programs need to be tightly coordinated so that different cell types are generated in the correct numbers for appropriate tissue size and function. Pancreatic dysfunction results in some of the most debilitating and fatal diseases, including pancreatic cancer and diabetes. Several transcription factors regulating pancreas lineage specification have been identified, and Notch signalling has been implicated in lineage allocation, but it remains unclear how these processes are coordinated. Using a combination of genetic approaches, organotypic cultures of embryonic pancreata, and genomics, we found that sphingosine-1-phosphate (S1p), signalling through the G protein coupled receptor (GPCR) S1pr

SUBMITTER: Serafimidis I 

PROVIDER: S-EPMC5331964 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature