MicroRNA screening identifies miR-134 as a regulator of poliovirus and enterovirus 71 infection.

ABSTRACT: MicroRNAs (miRNAs) regulate virus replication through multiple mechanisms. Poliovirus causes a highly debilitating disease and though global efforts to eradicate polio have sharply decreased polio incidence, unfortunately three countries (Afghanistan, Nigeria and Pakistan) remain polio-endemic. We hypothesize that understanding the host factors involved in polio replication will identify novel prophylactic and therapeutic targets against polio and related viruses. In this data set, employing genome wide screens of miRNA mimics and inhibitors, we identified miRNAs which significantly suppressed polio replication. Specifically, miR-134 regulates poliovirus replication via modulation of ras-related nuclear protein (RAN), an important component of the nuclear transport system. MiR-134 also inh

SUBMITTER: Orr-Burks NL 

PROVIDER: S-EPMC5332013 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature