Altered regulation and expression of genes by BET family of proteins in COPD patients.

ABSTRACT:

Background

BET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators. BET proteins bind to acetylated lysine residues in the histones of nucleosomal chromatin and function either as co-activators or co-repressors of gene expression. An imbalance between HAT and HDAC activities resulting in hyperacetylation of histones has been identified in COPD. We hypothesized that pan-BET inhibitor (JQ1) treatment of BET protein interactions with hyperacetylated sites in the chromatin will regulate excessive activation of pro-inflammatory genes in key inflammatory drivers of alveolar macrophages (AM) in COPD.

Methods and findings

Transcriptome analysis of AM from COPD patients indicated up-regulati

SUBMITTER: Malhotra R 

PROVIDER: S-EPMC5332090 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature