Chemical Tools To Monitor and Manipulate Adaptive Immune Responses.

ABSTRACT: Methods to monitor and manipulate the immune system are of enormous clinical interest. For example, the development of vaccines represents one of the earliest and greatest accomplishments of the biomedical research enterprise. More recently, drugs capable of "reawakening" the immune system to cancer have generated enormous excitement. But, much remains to be done. All drugs available today that manipulate the immune system cannot distinguish between "good" and "bad" immune responses and thus drive general and systemic immune suppression or activation. Indeed, with the notable exception of vaccines, our ability to monitor and manipulate antigen-specific immune responses is in its infancy. Achieving this finer level of control would be highly desirable. For example, it might allow the pharma

SUBMITTER: Doran TM 

PROVIDER: S-EPMC5332222 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature