Mathematical Modeling of <i>Streptococcus pneumoniae</i> Colonization, Invasive Infection and Treatment.

ABSTRACT: Streptococcus pneumoniae (Sp) is a commensal bacterium that normally resides on the upper airway epithelium without causing infection. However, factors such as co-infection with influenza virus can impair the complex Sp-host interactions and the subsequent development of many life-threatening infectious and inflammatory diseases, including pneumonia, meningitis or even sepsis. With the increased threat of Sp infection due to the emergence of new antibiotic resistant Sp strains, there is an urgent need for better treatment strategies that effectively prevent progression of disease triggered by Sp infection, minimizing the use of antibiotics. The complexity of the host-pathogen interactions has left the full understanding of underlying mechanisms of

SUBMITTER: Dominguez-Huttinger E 

PROVIDER: S-EPMC5332394 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature