Divergent Neuroinflammatory Regulation of Microglial TREM Expression and Involvement of NF-κB.

ABSTRACT: The triggering receptor expressed on myeloid cells (TREM) family of proteins are cell surface receptors with important roles in regulation of myeloid cell inflammatory activity. In the central nervous system, TREM2 is implicated in further roles in microglial homeostasis, neuroinflammation and neurodegeneration. Different TREM receptors appear to have contrasting roles in controlling myeloid immune activity therefore the relative and co-ordinated regulation of their expression is important to understand but is currently poorly understood. We sought to determine how microglial TREM expression is affected under neuroinflammatory conditions in vitro and in vivo. Our data show that microglial Trem1 and Trem2 gene expression are regulated in an opposing manner by lip

SUBMITTER: Owens R 

PROVIDER: S-EPMC5332401 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature