The relationship between pharmacokinetic parameters of carbamazepine and therapeutic response in epileptic patients.

ABSTRACT:

Introduction

The prescribed dose and carbamazepine plasma concentration to achieve the optimal therapeutic efficacy are highly variable from one patient to the other. Our study aimed to determine whether biological parameters may be used as plasma markers that can individually adjust the carbamazepine dose necessary to optimize therapeutic efficacy.

Material and methods

Ninety-four epileptic patients under carbamazepine monotherapy and who have never used combination therapy were recruited from the consecutive admissions at the Department of Neurology "CHU Sahloul" of Sousse Central Hospital in Tunisia from February 2010 to April 2011. The patients were monitored for epilepsy for three years on average. Carbamazepine and 10,11-epoxide-carbamazepine concentrations were analyz

SUBMITTER: Chbili C 

PROVIDER: S-EPMC5332445 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature