Dataset Information

Expansions of Cytotoxic CD4⁺CD28^- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection.

ABSTRACT: A large proportion of cardiovascular (CV) pathology results from immune-mediated damage, including systemic inflammation and cellular proliferation, which cause a narrowing of the blood vessels. Expansions of cytotoxic CD4⁺ T cells characterized by loss of CD28 ("CD4⁺CD28^- T cells" or "CD4⁺CD28^null cells") are closely associated with cardiovascular disease (CVD), in particular coronary artery damage. Direct involvement of these cells in damaging the vasculature has been demonstrated repeatedly. Moreover, CD4⁺CD28^- T cells are significantly increased in rheumatoid arthritis (RA) and other autoimmune conditions. It is striking that expansions of this subset beyond 1-2% occur exclusively in CMV-infected people. CMV i

SUBMITTER: Broadley I

PROVIDER: S-EPMC5332470 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature

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Dataset Information

Expansions of Cytotoxic CD4⁺CD28^- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Expansions of Cytotoxic CD4+CD28- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Expansions of Cytotoxic CD4⁺CD28^- T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection.