White matter hyperintensity lesion burden is associated with the infarct volume and 90-day outcome in small subcortical infarcts.

ABSTRACT:

Objectives

Small subcortical infarcts (SSI) frequently coexist with brain white matter hyperintensity (WMH) lesions. We sought to determine whether preexisting WMH burden relates to SSI volume, SSI etiology, and 90-day functional outcome.

Materials and methods

We retrospectively studied 80 consecutive patients with acute SSI. Infarct volume was determined on diffusion weighted imaging, and WMH burden was graded on fluid-attenuated inversion recovery sequences according to the Fazekas scale. SSI etiology was categorized as small vessel disease (SVD) vs non-SVD related. Multivariable linear and logistic regression models were constructed to determine whether WMH burden was independently associated with the SSI volume and a poor 90-day outcome (modified Rankin scale [mRS] score

SUBMITTER: Helenius J 

PROVIDER: S-EPMC5332524 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature