Chemical Shift magnetization transfer magnetic resonance imaging.

ABSTRACT:

Purpose

The purpose of this work was to develop a chemical shift magnetization transfer (CSMT) magnetic resonance imaging (MRI) method to provide accurate magnetization transfer ratio (MTR) measurements in the presence of fat.

Methods

Numerical simulations were performed to compare MTR measurements at different echo times (TEs) for voxels with varying fat/water content. The CSMT approach was developed using water fraction estimates to correct for the impact of fat signal upon observed MTR measurements. The CSMT method was validated with oil/agarose phantom and animal studies.

Results

Simulations demonstrated that the observed MTRs vary with water fraction as well as with the TE-dependent phase difference between fat and water signals; simulations also showed that a li

SUBMITTER: Li W 

PROVIDER: S-EPMC5332527 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature