Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology.

ABSTRACT: Children with an anxious temperament are prone to heightened shyness and behavioral inhibition (BI). When chronic and extreme, this anxious, inhibited phenotype is an important early-life risk factor for the development of anxiety disorders, depression and co-morbid substance abuse. Individuals with extreme anxious temperament often show persistent distress in the absence of immediate threat and this contextually inappropriate anxiety predicts future symptom development. Despite its clear clinical relevance, the neural circuitry governing the maladaptive persistence of anxiety remains unclear. Here, we used a well-established nonhuman primate model of childhood temperament and high-resolution ¹⁸fluorodeoxyglucose positron emission tomography (FDG-PET) imaging to understand the n

SUBMITTER: Shackman AJ 

PROVIDER: S-EPMC5332536 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature