Neutrophil Counts and Initial Presentation of 12 Cardiovascular Diseases: A CALIBER Cohort Study.

ABSTRACT:

Background

Neutrophil counts are a ubiquitous measure of inflammation, but previous studies on their association with cardiovascular disease (CVD) were limited by small numbers of patients or a narrow range of endpoints.

Objectives

This study investigated associations of clinically recorded neutrophil counts with initial presentation for a range of CVDs.

Methods

We used linked primary care, hospitalization, disease registry, and mortality data in England. We included people 30 years or older with complete blood counts performed in usual clinical care and no history of CVD. We used Cox models to estimate cause-specific hazard ratios (HRs) for 12 CVDs, adjusted for cardiovascular risk factors and acute conditions affecting neutrophil counts (such as infections and cance

SUBMITTER: Shah AD 

PROVIDER: S-EPMC5332591 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature